What is the Harm of Diabetic Nephropathy?

Diabetic Nephropathy refers to long-time Diabetes resulting in kidney damage. The main symptoms are protienuria (protein in the urine) and high blood pressure. So, what is the harm of Diabetic Nephropathy? Experts in Beijing Yumei Kidney Disease Hospital told us that the harms of Diabetic Nephropathy include:
1. patients’mental stress and agony. For people with and without kidney disease, there physical condition and life quality are different, as well as threat and mental stress.
2. Resulting in death. Although Diabetic Nephropathy is not like heart disease that easily leads to sudden death, it is a primary cause for patients with Diabetes to result in death. In clinic practice, the main death population of Diabetic Nephropathy is Type ⅠDiabetes. Because, patients with Type ⅠDiabetes are occurring at the early age, the progression is rapid, and the kidney function is poor, finally all patients will appear damage in heart, cerebrovascular, and kidneys. In addition, kidney disease will lead to disability. For example, patients with dialysis will have a different life from the healthy people
3. Resulting in huge economic waste. For example, if patients need dialysis, they must require dialysis twice a week at least, which will bring a large economic burden. Also, the work and manual labor will be affected, which is also a waste.
So, we should try to avoid having Diabetic Nephropathy. We can’t make all people avoid Diabetes, But we can try our best minimize the number of Diabetic Nephropathy. Even people have had Diabetic Nephropathy, we should try to slow down its progression to Uremia and avoid dying early.

If you have any questions, please contact our expert online.

The reason for the high urinary protein , what does ?

About the reasons for the high urinary protein in question what has long been plagued believe everyone , many people have vague high urine protein indicates that our kidneys may have been a problem. But there are reasons for the high urinary protein which problem is not very clear , the following description of experts take a look at it!

The reason for the high urinary protein 1,24 hour urine protein of normal reference value of 10 to 150 mg. If 150 to 500 mg of microalbuminuria , > 500 mg for clinical proteinuria. Tip microalbuminuria in early diabetic nephropathy , need long-term control of blood glucose , to reverse or delay the incidence of nephropathy and retinopathy development has a certain significance.

The reason for the high urinary protein 2 , urinary albumin excretion rate (uAE) normal reference value < 15 micrograms / min. Early diabetic nephropathy , glomerular basement membrane damage is light, so that only albumin leakage. Early diabetic nephropathy uAE 15 to 200 micrograms / min, clinical diabetic nephropathy > 200 micrograms / min. Experts have reported significant proteinuria in diabetic nephropathy , almost 100% of diabetic retinopathy. When diabetics uAE30 micrograms / min, may be the key moment of microvascular complications of diabetes prevention . After the strict control of blood glucose, urine albumin early diabetic nephropathy can be reversed or partially reversed .

The reason for the high urinary protein , what does ?
By introducing these experts, we are not all clear yet , kidney specialists remind you: any one person is a part of the family , friends, busy work, health is equally important . Want to make your own life better , then have a healthy body is a top priority . Our nephrologist day online , you can consult our experts free .

High urine protein is how it happened Cause

High urine protein is how it happened ? Many people in life have appeared symptoms of urinary protein is high , for that matter , many people are confused. So, in the end the high urinary protein is how it happened ? I hope the following description can give us some help .

For high urine protein is how problems , experts say , proteinuria as chronic nephritis most common clinical manifestations . For a long time , has been considered the result of kidney disease. In fact , the amount of urinary protein and abnormal is not only an indicator of disease , but as an independent factor involved in the process of kidney disease . The study also found that the speed levels and a variety of chronic renal failure, nephrotic proteinuria progress is closely related to be able to make any therapeutic intervention to reduce proteinuria are conducive to slow the progression of kidney disease.

High urine protein is how it happened ? Although proteinuria as an independent factor involved in the process of kidney disease , proteinuria can also damage the kidneys . Performance in the following areas :
1 , urine protein on mesangial cells have toxic effects , patients entering renal failure, there will be a large number of plasma protein deposition in mesangial areas, these macromolecules in mesangial deposition can cause system cell membrane damage , on cell proliferation and mesangial matrix production increase, leading to glomerulosclerosis ;

2 , urine protein can damage tubulointerstitial normal glomerular filtration of small amounts of small molecule protein is close reabsorption in renal tubular epithelial cells , decomposed in the lysosomes. Under pathological conditions , increased glomerular permeability to make a lot of plasma protein leakage into the tubule lumen , and proximal tubular epithelial cells leads to excessive reabsorption of albumin in the cytoplasm lysosomal activity increased , can cause cell damage ;
3 , proteinuria increased renal tubular reabsorption of protein to promote increased production of ammonia , the ammonia generated in the renal tissue during interstitial lesions also play a role. In addition, the re- absorb and digest large amounts of protein extra energy, which can cause tubule cells of oxygen, oxygen free radicals increases , causing a small tube cell damage.
High urine protein is how it happened ? Diseases caused by increased urinary protein What ?

[ Nephritis ] acute nephritis or chronic nephritis , the urine protein from day to tens of grams have a small amount .
[ Nephrotic syndrome ] day volume of urine will be a lot more than three grams of protein in the urine . When symptoms are severe , oozing of urine protein will reduce the concentration of protein in the blood . In addition , there are also a result of diabetic kidney disease, amyloidosis (AJnyloidosis), the situation caused by diseases such as collagen .

[ Renal sclerosis ] With the state of renal sclerosis induced hypertension , urinary protein excretion is reduced, mostly in 300 mg or less.
In addition, multiple myeloma, systemic lupus erythematosus, rheumatoid arthritis , gout, edema disease , such as mercury poisoning, lead poisoning disease , there will be urine protein .

High urine protein is how it happened ? When a situation occurs when higher urinary protein in urine routine examination , first stay calm , do not panic , this time is not necessarily a high urine protein pathological reasons. So the possibility of kidney disease should first investigation , if necessary, to do it again urine routine examination. Better inspections urinary protein , you must do the inspection. When re- inspection is still abnormal , we must accept the urinary sediment , check the number of red blood cells , white blood cell count , etc. , but also the implementation of the kidneys and urinary tract precision inspection , and a comprehensive systemic symptoms to diagnose whether there is kidney disease or any other disease. When you have kidney disease , but also do other renal function tests , do a comprehensive diagnosis. Diagnosis of cystitis, pyelonephritis, urinary tract infections , medication physician indicated .
High above for urine protein by how it related presentations , we hope to have some help . If you have any questions, or around other kidney disease patients also had a similar case, the patient's case suggested that it might submit information to this website experts with specific conditions to give you more detailed guidance and analysis. You can also click consulting kidney specialists , experts will be happy to help patients recover.

High urine protein is how experts interpret the matter

In constant development and social progress, people's living standard has been improved , we have more and more attention to their own health . So many people have the habit of regular physical examination , but when we discovered that their high urine protein when high urine protein did not know how it is, here I 'll tell you about the hospital experts proteinuria is how high going issues now !

For high urine protein is how going on , experts said, only a small amount of urine protein in urine during normal , routine qualitative examination was negative , 24-hour urine protein <100mg. When the urine within the urinary protein content than 150mg/24h, positive or conventional qualitative methods , called urinary proteinuria. Physiological urinary proteinuria seen in heat , cold, high temperature , strenuous exercise or labor, and orthostatic proteinuria in urine ; pathological proteinuria in urine for a variety of primary or secondary diseases caused by urinary proteinuria, urinary protein actually biased high is how it happened ? What are the reasons ?

Patients with high proteinuria , nephropathy should consider the most , because most likely lead to kidney urinary protein . Under normal circumstances , urine protein will be absorbed back situation if kidney damage occurs , the development of renal fibrosis in accordance with the principles that started renal fibrosis , renal functional decline back to the absorption occurs , it will leak some of urinary protein , resulting in produce urine protein , urinary protein high. Proteinuria is how high the patient's treatment is very helpful .


For a detailed description by the above is how high urinary protein , we are clear on this issue now ! Experts advise: patients with specific conditions for their own situation to find the reason for the high urinary protein , and thus take preventive measures , so as to play a real role in prevention. If you have additional questions, please consult the online experts . Finally, I wish you good health !

Patients with renal failure is how high urine protein ?

Urinary protein found in patients with renal failure is high when the examination how it happened? Impact on patients is very large, a lot of friends in high urinary protein finds himself did not care about the final result in a more severe consequences, then the partial proteinuria in patients with renal failure high is how it happened? this means that it? us listen to the experts associated introduce it .

Patients with renal failure is how high urine protein ? Mean renal cell damage kidney failure microalbuminuria great extent on the high side , but there are unexpected place, such as emission night before the next day 's morning urine has may contain protein . If the body has a problem , the situation is reflected in the urine protein should be more than one , there should be , red blood cells, hemoglobin . In order to be assured that everyone is better still to the hospital.

Urinary protein , blood Central Standing Committee have indispensable to human life activity protein exists. Patients with renal failure is how high urine protein ? Portion of protein filaments filters in the kidneys into the urine sphere , but it will be absorbed in the renal tubules and returned the blood. Therefore, if the kidney function is normal, the amount of protein in the urine that appears only a little , but when the kidneys and urinary disorders will appear leaking large amounts of protein becomes proteinuria.


Through the above correlation , I believe everyone on the high urinary protein in patients with renal failure is how it has a certain understanding of it, if you have questions or would like to learn more about kidney disease information , you can now free online consultation, experts will you make the most detailed description to help you solve the problem !

What Are the Tests for Proteinuria?

To test for proteinuria, you will need to give a urine sample. A strip of chemically treated paper will change color when dipped in urine that has too much protein. A more sophisticated chemical analysis is needed to find smaller amounts (microalbuminuria). The most dependable measure of proteinuria requires you to collect your urine for 24 hours.

You will be given a special container and instructions for starting and stopping the collection and for storing the container.

How Is Proteinuria Treated?
If you have diabetes, hypertension, or both, the first goal of treatment will be to control your blood sugar and blood pressure. If you have diabetes, you should test your blood sugar often, follow a healthy eating plan, take your medicines, and get plenty of exercise. If you have diabetes and high blood pressure, your doctor may prescribe a medicine from a class of drugs called ACE (angiotensin-converting enzyme) inhibitors. These drugs have been found to protect kidney function even more than other drugs that provide the same level of blood pressure control.

People who have high blood pressure and proteinuria but not diabetes may also benefit from taking an ACE inhibitor. The National Heart, Lung, and Blood Institute recommends keeping blood pressure below 125/75 mm Hg for people with proteinuria greater than 1 gram per 24 hours.


In addition to blood sugar and blood pressure control, the National Kidney Foundation recommends restricting dietary salt and protein. Your doctor may refer you to a dietitian to help you follow a healthy eating plan.

What does proteinuria mean?

Proteinuria describes a condition in which urine contains an abnormal amount of protein. Proteins are the building blocks for all body parts, including muscles, bones, hair, and nails. Proteins in your blood also perform a number of important functions: protecting you from infection, helping your blood coagulate, and keeping the right amount of fluid circulating through your body.
As blood passes through healthy kidneys, they filter the waste products out and leave in the things the body needs, like proteins. Most proteins are too big to pass through the kidneys' filters into the urine, unless the kidneys are damaged. The two proteins that are most likely to appear in urine are albumin and globulin. Albumin is smaller and therefore more likely to escape through the filters of the kidney, called glomeruli. Albumin's function in the body includes retention of fluid in the blood. It acts like a sponge, soaking up fluid from body tissues.


Inflammation in the glomeruli is called glomerulonephritis, or simply nephritis. Many diseases can cause this inflammation, which leads to proteinuria. Additional processes that can damage the glomeruli and cause proteinuria include diabetes, hypertension, and other forms of kidney diseases.


Research shows that the level and type of proteinuria (whether the urinary proteins are only albumin or include other proteins) strongly determine the extent of damage and whether you are at risk for developing progressivekidney failure.


Proteinuria has also been shown to be associated with cardiovascular disease. Damaged blood vessels may lead to heart failure or stroke as well as kidney failure. If your doctor finds that you have proteinuria, you will want to do what you can to protect your health and prevent any of these diseases from developing.
Several health organizations recommend that some people be regularly checked for proteinuria so that kidney disease can be detected and treated before it progresses. A 1996 study sponsored by the National Institutes of Health determined that proteinuria is the best predictor of progressive kidney failure in people with type 2 diabetes. The American Diabetes Association recommends regular urine testing for proteinuria for people with type 1 or type 2 diabetes. The National Kidney Foundation recommends that routine checkups include testing for excess protein in the urine, especially for people in high-risk groups.

Who Is at Risk?
People with diabetes, hypertension, or certain family backgrounds are at risk for proteinuria. In the United States, diabetes is the leading cause of end-stage renal disease (ESRD), the result of progressive kidney failure. In both type 1 and type 2 diabetes, the first sign of deteriorating kidney function is the presence of small amounts of the protein albumin in the urine, called microalbuminuria. As kidney function declines, the amount of albumin in the urine increases, and microalbuminuria becomes full-fledged proteinuria.


High blood pressure is the second leading cause of ESRD. Proteinuria in people with high blood pressure is an indicator of declining kidney function. If the hypertension is not controlled, the person can progress to full renal failure.
African Americans are more likely than white Americans to have high blood pressure and to develop kidney problems from it, even when their blood pressure is only mildly elevated. In fact, African Americans ages 25 to 44 are 20 times more likely than their white counterparts to develop hypertension-related kidney failure. High blood pressure is the leading cause of kidney failure among African Americans.


Other groups at risk for proteinuria are American Indians, Hispanic Americans, Pacific Islander Americans, older people, and overweight people. People who have a family history of kidney disease should also have their urine tested regularly.
What Are the Signs of Proteinuria and Kidney Failure?
Large amounts of protein in your urine may cause it to look foamy in the toilet. Also, because the protein has left your body, your blood can no longer soak up enough fluid and you may notice swelling in your hands, feet, abdomen, or face. Alternatively, you may have proteinuria without noticing any signs or symptoms. Testing is the only way to find out how much protein you have in your urine.

My dad has high protien in his urine what does that mean.

Proteinuria describes a condition in which urine contains an abnormal amount of protein. Proteins are the building blocks for all body parts, including muscles, bones, hair, and nails. Proteins in your blood also perform a number of important functions. They protect you from infection, help your blood clot, and keep the right amount of fluid circulating throughout your body.
As blood passes through healthy kidneys, they filter the waste products out and leave in the things the body needs, like proteins. Most proteins are too big to pass through the kidneys' filters into the urine unless the kidneys are damaged. The main protein that is most likely to appear in urine is albumin. Proteins from the blood can escape into the urine when the filters of the kidney, called glomeruli, are damaged. Sometimes the term albuminuria is used when a urine test detects albumin specifically. Albumin's function in the body includes retention of fluid in the blood. It acts like a sponge, soaking up fluid from body tissues.
Inflammation in the glomeruli is called glomerulonephritis, or simply nephritis. Many diseases can cause this inflammation, which leads to proteinuria. Additional processes that can damage the glomeruli and cause proteinuria include diabetes, hypertension, and other forms of kidney diseases.

Proteinuria is also associated with cardiovascular disease. Damaged blood vessels may lead to heart failure or stroke as well as kidney failure. If your doctor finds that you have proteinuria, do what you can to protect your health and prevent any of these diseases from developing.

High serum creatinine, diabetes, high blood pressure. what can i do?

There are 3 key steps to controlling glucose levels for pre diabetes:
1) EXERCISE- Walking is fine but Nordic Walking is Great. Exercise also lowers Glucose levels , lowers Cholesterol and lowers Blood Pressure. Google it.Exercise is Non-Negotiable !!!Thats why it is Number 1 on the list.
2) Knowledge- http://www.kidneyservicechina.com/  This is a great site for info
3)Diet- A low carb diet is in order. I can't count carbs so I use Mendosa's Glycemic Index Diet. Great for the whole family. http://www.mendosa.com/gilists.htm
Early chronic renal insufficiency (Stages 1 to 2)
Physical symptoms. Usually few or no physical symptoms that you can feel (other than those you may experience if you have heavy proteinuria).
Blood work. Blood work results will show abnormalities - mainly a slightly elevated serum creatinine. Note that there is often a time lag between elevations of serum creatinine, and some progression of the IgAN. By the time serum creatinine is elevated, the person may already have lost 50% of kidney function.
Urinalysis. Urine will show abnormalities. Urine can be checked by dipstick in the doctor's office (as an initial check), and followed up with a more complete urinalysis. The main urine abnormality that will suggest a kidney disease is the presence of protein and/or blood. Either will usually trigger further investigation. However, blood and/or protein in the urine doesn't say anything about actual kidney function.
Treatment. Treatment may involve some mild dietary changes (a lower protein diet may in some cases be recommended), and a blood pressure medication may be prescribed (usually of the ACE inhibitor class, the angiotensin II receptor class, or both, even if blood pressure is not really elevated much).
Blood pressure. Some people start having high blood pressure even in early chronic renal failure. IgAN is one kidney disease that can do this.
Anemia. Anemia may rarely occur at this stage. In this case, it is most often caused by having heavy proteinuria rather than actual chronic renal insufficiency.
Treatment
Diet. Dietary changes may be ordered (renal diet: low protein, low potassium, low phosphorus, low sodium, higher calorie)
Medication
High blood pressure medications. It's common to need more than one at this stage, and often 3 or more.
Other drugs/supplements. May be prescribed if needed, such as vitamin D analog (calcitriol is a common one), renal vitamins (not a regular multi-vitamin, as these contain too much vitamin A for the typical advanced renal insufficiency patient). Drugs for controlling heavy proteinuria if necessary (note that heavier proteinuria does not automatically follow with more advanced chronic renal insufficiency).

Phosphorus binder. You may be asked to begin taking a calcium supplement with meals as a phosphorus binder (or a medication may be prescribed instead of or in addition to calcium).

What are the causes of proteinuria?

Proteinuria may be a feature of the following conditions:
Nephrotic syndromes (i.e. intrinsic renal failure)
Pre-eclampsia
Eclampsia
Toxic lesions of kidneys
Collagen vascular diseases (e.g. systemic lupus erythematosus)
Dehydration
Glomerular diseases, such as membranous glomerulonephritis, focal segmental glomerulonephritis, minimal change disease (lipoid nephrosis)
Strenuous exercise
Stress
Benign orthostatic (postural) proteinuria
Focal segmental glomerulosclerosis (FSGS)
IgA nephropathy (i.e. Berger's disease)
IgM nephropathy
Membranoproliferative glomerulonephritis
Membranous nephropathy
Minimal change disease
Sarcoidosis
Alport's syndrome
Diabetes mellitus (diabetic nephropathy)
Drugs (e.g. NSAIDs, nicotine, penicillamine, gold and other heavy metals, ACE inhibitors, antibiotics, or opiates (especially heroin)
Fabry's disease
Infections (e.g. HIV, syphilis, hepatitis, poststreptococcal infection, urinary schistosomiasis)
Aminoaciduria
Fanconi syndrome
Hypertensive nephrosclerosis
Interstitial nephritis
Sickle cell disease
Hemoglobinuria
Multiple myeloma
Myoglobinuria
Organ rejection: Kidney transplant patients may have gamma-globulins in their urine if the kidneys start to reject.
Ebola hemorrhagic fever
Nail patella syndrome
Familial Mediterranean fever
HELLP Syndrome
Systemic lupus erythematosus
Wegener's granulomatosis
Rheumatoid arthritis
Glycogen storage disease type 1
Goodpasture's syndrome
Henoch Schonlein Purpura
A urinary tract infection which has spread to the kidney(s)

I know that's not overly helpful, but there are some fairly benign causes (drug causes) to severe ones like Lupus.