Hypertensive nephropathy (or "hypertensive nephrosclerosis", or
"Hypertensive renal disease") is a medical condition referring to damage to the
kidney due to chronic high blood pressure.
It should be distinguished from "renovascular hypertension" , which is a
form of secondary hypertension.
In the kidneys, as a result of benign arterial hypertension, hyaline (pink,
amorphous, homogeneous material) accumulates in the wall of small arteries and
arterioles, producing the thickening of their walls and the narrowing of the
lumens — hyaline arteriolosclerosis. Consequent ischemia will produce tubular
atrophy,interstitial fibrosis, glomerular alterations (smaller glomeruli with
different degrees of hyalinization - from mild to sclerosis of glomeruli) and
periglomerular fibrosis. In advanced stages, renal failure will occur.
Functional nephrons have dilated tubules, often with hyaline casts in the
lumens.
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