Kidney failure can occur from an acute situation or from chronic
problems.
In acute renal failure, kidney function is lost rapidly and can occur from
a variety of insults to the body. The list of causes is often categorized based
on where the injury has occurred.
Prerenal causes (pre=before + renal=kidney) causes are due to decreased
blood supply to the kidney. Examples of prerenal causes are:
Hypovolemia (low blood volume) due to blood loss
Dehydration from loss of body fluid (vomiting, diarrhea, sweating, fever
)
Poor intake of fluids
Medication, for example, diuretics ("water pills") may cause excessive
water loss.
Loss of blood supply to the kidney due to obstruction of the renal artery
or vein.
Renal causes (damage directly to the kidney itself) include:
Sepsis: The body's immune system is overwhelmed from infection and causes
inflammation and shutdown of the kidneys. This usually does not occur with
urinary tract infections.
Medications: Some medications are toxic to the kidney, including
nonsteroidal anti-inflammatory drugs like ibuprofen and naproxen. Others are
antibiotics like aminoglycosides [gentamicin (Garamycin), tobramycin], lithium
(Eskalith, Lithobid), iodine-containing medications such as those injected for
radiology dye studies.
Rhabdomyolysis: This is a situation in which there is significant muscle
breakdown in the body, and the degeneration products of muscle fibers clog the
filtering system of the kidneys. Often occurring because of trauma and crush
injuries, it can also be caused by some medications used to treat high
cholesterol.
Multiple Myeloma
Acute glomerulonephritis or inflammation of the glomeruli, the filtering
system of the kidneys. Many diseases can cause this inflammation including
systemic lupus erythematosus, Wegener's granulomatosis, and Goodpasture
syndrome.
Post renal causes (post=after + renal= kidney) are due to factors that
affect outflow of the urine:
Obstruction of the bladder or the ureters can cause back pressure when
there is no place for the urine to go as the kidneys continue to work. When the
pressure increases enough, the kidneys shut down.
Prostatic hypertrophy or prostate cancer may block the urethra and prevents
the bladder from emptying.
Tumors in the abdomen that surround and obstruct the ureters.
Kidney stones
Chronic renal failure develops over months and years. The most common
causes of chronic renal failure are related to:
Poorly controlled diabetes
Poorly controlled high blood pressure
Chronic glomerulonephritis
Less common causes:
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